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Pancreatic islet overproduction of H2S and suppre... F1000 Biology Hidden jewels Top10
This is an important paper reporting that, in the Zucker rat model, abnormally high production of hydrogen sulfide, the gaseous neurotransmitter, impairs the release of insulin by pancreatic islet cells. This is an exciting finding that significantly advances our understanding of the mechanism for impaired insulin release in diabetes.
Longitudinal decline in lung volume in a populati... F1000 Mdicine Hidden jewels Top10
This is one of only three published studies on the topic of longitudinal changes in lung function in children. It provides evidence that patients with sickle cell disease (SCD) experience gradual but continuous decline in lung volume and function that starts in childhood and continues throughout adulthood. The study is important for all physicians involved in the care of patients with SCD because it emphasizes the need for early and close follow-up and raises the possibility of early intervention(s) that could potentially prevent, delay, or modify the course of the disease.

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